Pincus Lab

Washington University School of Medicine

Department of Developmental Biology
and Department of Genetics

For further information, consult Google Scholar or PubMed.

  1. Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, Yang C, Phillips G, McBay D, Zhang WB, Partridge L, Pincus Z & Gems D.
    Two forms of death in ageing Caenorhabditis elegans.
    Nat Commun 8 p. 15458 (2017). pubmed | journal
  2. Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N & Pincus Z.
    Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health.
    Cell Systems 3 pp. 333–345.e4 (2016). pubmed | journal
  3. Weicksel SE, Mahadav A, Moyle M, Cipriani PG, Kudron M, Pincus Z, Bahmanyar S, Abriola L, Merkel J, Gutwein M, Fernandez AG, Piano F, Gunsalus KC & Reinke V.
    A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans.
    Development 143 pp. 3540–3548 (2016). pubmed | journal
  4. Kinser HE & Pincus Z.
    High-throughput screening in the C. elegans nervous system.
    Mol Cell Neurosci (2016). pubmed | journal
  5. Pincus Z, Mazer TC & Slack FJ.
    Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green.
    Aging 8 pp. 889–898 (2016). pubmed | journal
  6. Pincus Z.
    Ageing: A stretch in time.
    Nature 530 pp. 37–38 (2016). pubmed | journal
  7. Zhang WB & Pincus Z.
    Predicting all-cause mortality from basic physiology in the Framingham Heart Study.
    Aging Cell 15 pp. 39–48 (2016). pubmed | journal
  8. Martinez LE, Hardcastle JM, Wang J, Pincus Z, Tsang J, Hoover TR, Bansil R & Salama NR.
    Helicobacter pylori strains vary cell shape and flagellum number to maintain robust motility in viscous environments.
    Mol Microbiol (2015). pubmed | journal
  9. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM & Slack FJ.
    MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.
    Nature 518 pp. 107–110 (2015). pubmed | journal
  10. Sycuro LK, Rule CS, Petersen TW, Wyckoff TJ, Sessler T, Nagarkar DB, Khalid F, Pincus Z, Biboy J, Vollmer W & Salama NR.
    Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology.
    Mol Microbiol 90 pp. 869–883 (2013). pubmed | journal
  11. Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards S, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K & Gems D.
    Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans.
    PLoS Biol 11 p. e1001613 (2013). pubmed | journal
  12. Tevy MF, Giebultowicz J, Pincus Z, Mazzoccoli G & Vinciguerra M.
    Aging signaling pathways and circadian clock-dependent metabolic derangements.
    Trends Endocrinol Metab 24 pp. 229–237 (2013). pubmed | journal
  13. Yam PT, Pincus Z, Gupta GD, Bashkurov M, Charron F, Pelletier L & Colman DR.
    N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons.
    PLoS ONE 8 p. e79679 (2013). pubmed | journal
  14. Sycuro LK, Wyckoff TJ, Biboy J, Born P, Pincus Z, Vollmer W & Salama NR.
    Multiple Peptidoglycan Modification Networks Modulate Helicobacter pylori{\textquoteright}s Cell Shape, Motility, and Colonization Potential.
    PLoS Pathog 8 p. e1002603 (2012). pubmed | journal
  15. Pincus Z, Smith-Vikos T & Slack FJ.
    MicroRNA Predictors of Longevity in Caenorhabditis elegans
    PLoS Genet 7 p. e1002306 (2011). pubmed | journal
  16. Zhou KI, Pincus Z & Slack FJ.
    Longevity and stress in Caenorhabditis elegans.
    Aging 3 pp. 733–753 (2011). pubmed | journal
  17. Dye NA, Pincus Z, Fisher IC, Shapiro L & Theriot JA.
    Mutations in the nucleotide binding pocket of MreB can alter cell curvature and polar morphology in Caulobacter.
    Mol Microbiol 81 pp. 386–394 (2011). pubmed | journal
  18. de Lencastre A, Pincus Z, Zhou K, Kato M, Lee SS & Slack FJ.
    MicroRNAs both promote and antagonize longevity in C. elegans.
    Curr Biol 20 pp. 2159–2168 (2010). pubmed | journal
  19. Sycuro LK, Pincus Z, Gutierrez KD, Biboy J, Stern CA, Vollmer W & Salama NR.
    Peptidoglycan crosslinking relaxation promotes Helicobacter pylori{\textquoteright}s helical shape and stomach colonization.
    Cell 141 pp. 822–833 (2010). pubmed | journal
  20. Pincus Z & Slack FJ.
    Developmental biomarkers of aging in Caenorhabditis elegans.
    Dev Dyn 239 pp. 1306–1314 (2010). pubmed | journal
  21. Kato M, de Lencastre A, Pincus Z & Slack FJ.
    Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development.
    Genome Biol 10 p. R54 (2009). pubmed | journal
  22. Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A & Theriot JA.
    Mechanism of shape determination in motile cells.
    Nature 453 pp. 475–480 (2008). pubmed | journal
  23. Pincus Z & Slack FJ.
    Transcriptional (dys)regulation and aging in Caenorhabditis elegans.
    Genome Biol 9 p. 233 (2008). pubmed | journal
  24. Lacayo CI, Pincus Z, VanDuijn MM, Wilson CA, Fletcher DA, Gertler FB, Mogilner A & Theriot JA.
    Emergence of large-scale cell morphology and movement from local actin filament growth dynamics.
    PLoS Biol 5 p. e233 (2007). pubmed | journal
  25. Pincus Z & Theriot JA.
    Comparison of quantitative methods for cell-shape analysis.
    J Microscopy 227 pp. 140–156 (2007). pubmed | journal
  26. Dye NA, Pincus Z, Theriot JA, Shapiro L & Gitai Z.
    Two independent spiral structures control cell shape in Caulobacter.
    Proc Natl Acad Sci USA 102 pp. 18608–18613 (2005). pubmed | journal
  27. Kaufer D, Ogle WO, Pincus Z, Clark KL, Nicholas AC, Dinkel KM, Dumas TC, Ferguson D, Lee AL, Winters MA & Sapolsky RM.
    Restructuring the neuronal stress response with anti-glucocorticoid gene delivery.
    Nat Neurosci 7 pp. 947–953 (2004). pubmed | journal
  28. O’Connor MJ, Buckeridge DL, Choy M, Crubezy M, Pincus Z & Musen MA.
    BioSTORM: a system for automated surveillance of diverse data sources.
    Proc AMIA Symp p. 1071 (2003). pubmed | journal
  29. Pincus Z & Musen MA.
    Contextualizing heterogeneous data for integration and inference.
    Proc AMIA Symp pp. 514–518 (2003). pubmed | journal